Transgenic Expression of CTLA-4 Controls Lymphoproliferation in IL-2-Deficient Mice
نویسندگان
چکیده
منابع مشابه
Transgenic expression of CTLA-4 controls lymphoproliferation in IL-2-deficient mice.
IL-2-deficient mice develop a lymphoproliferative and autoimmune disease characterized by autoimmune hemolytic anemia (AHA) and inflammatory bowel disease. We have previously reported that IL-2 is necessary for optimal up-regulation of CTLA-4, an inducible negative regulator of T cell activation. In this study, we have tested the hypothesis that reduced expression of CTLA-4 in IL-2-deficient T ...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2004
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.173.9.5415